Morphine tolerance in genetically selected rats induced by chronically elevated saccharin intake

Morphine tolerance in genetically selected rats induced by chronically elevated saccharin intake

Rats of line LC2-Hi that drank about 50 milliliters of a highly palatable saccharin solution daily for 28 consecutive days did not show morphine analgesia or an opioid form of stress-induced analgesia and were not responsive to naloxone. These findings support the idea that chronically elevated sacc...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1983-08, Vol.221 (4613), p.871-873
Hauptverfasser: Lieblich, I, Cohen, E, Ganchrow, J R, Blass, E M, Bergmann, F
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Drug Tolerance
Endorphins - physiology
Morphine - pharmacology
Pain - physiopathology
Rats
Saccharin - pharmacology
Stress, Physiological - physiopathology
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Zusammenfassung:Rats of line LC2-Hi that drank about 50 milliliters of a highly palatable saccharin solution daily for 28 consecutive days did not show morphine analgesia or an opioid form of stress-induced analgesia and were not responsive to naloxone. These findings support the idea that chronically elevated saccharin intake may cause increased release and utilization of endogenous opiates.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.6879185