Angiotensin Synthesis in the Brain and Increased Turnover in Hypertensive Rats

The missing link in the evidence for an active endogenous renin angiotensin system in the brain has been the demonstration of local angiotensin synthesis in the central nervous system in vivo. In this report the extraction and characterization of angiotensin I and angiotensin II from the brain of ra...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1983-08, Vol.221 (4613), p.869-871
Hauptverfasser:	Ganten, D., Hermann, K., Bayer, C., Th. Unger, Lang, R. E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin Angiotensin I - cerebrospinal fluid Angiotensin II - biosynthesis Angiotensinogen - metabolism Angiotensins Angiotensins - biosynthesis Animals Arterial hypertension. Arterial hypotension Biological and medical sciences Blood Blood and lymphatic vessels Brain Brain - metabolism Brain chemistry Cardiology. Vascular system Cerebrospinal fluid Experimental diseases Hormones Hypertension Hypertension - metabolism Kidneys Medical sciences Morphine Nephrectomy Neuroendocrinology Neuropeptides Neuropharmacology Opioid analgesics Radioimmunoassay Rats
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Beschreibung
Zusammenfassung:	The missing link in the evidence for an active endogenous renin angiotensin system in the brain has been the demonstration of local angiotensin synthesis in the central nervous system in vivo. In this report the extraction and characterization of angiotensin I and angiotensin II from the brain of rats is described. The accumulation of angiotensin I was enhanced in hypertensive rats when the conversion to angiotensin II was blocked in vivo by the converting enzyme inhibitor captopril.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.6879184