A new synthetic functionalized antigen carrier

A new synthetic functionalized antigen carrier

A new synthetic functionalized antigen carrier is described. It consists of a core of seven branched lysine residues, of which each of the four N‐terminal lysine residues contains two N‐(S‐acetylmercaptoacetyl)‐glutamyl residues. After removal of the protecting S‐acetyl groups affording eight thiol...

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Veröffentlicht in:International Journal of Peptide and Protein Research 1991-01, Vol.37 (1), p.27-32
Hauptverfasser: DRIJFHOUT, J. W., BLOEMHOFF, W.
Format: Artikel
Sprache:eng
Schlagworte:
3-nitro-2-pyridinesulfenyl (NPys)
Amino Acid Sequence
Antigens
Carrier Proteins - chemical synthesis
Carrier Proteins - chemistry
Carrier Proteins - immunology
Chemistry
Exact sciences and technology
Lysine
Molecular Sequence Data
Molecular Structure
multiple antigenic peptide (MAP)
Organic chemistry
Peptides
Preparations and properties
solid-phase peptide synthesis
unsymmetrical disulfide formation
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Beschreibung
Zusammenfassung:A new synthetic functionalized antigen carrier is described. It consists of a core of seven branched lysine residues, of which each of the four N‐terminal lysine residues contains two N‐(S‐acetylmercaptoacetyl)‐glutamyl residues. After removal of the protecting S‐acetyl groups affording eight thiol functions, the carrier can easily be conjugated to a properly functionalized antigen, e.g. an S‐(Npys)‐cysteinyl peptide, thus affording a high molecular weight conjugate with an unusually high antigen content.
ISSN:0367-8377
1399-3011
DOI:10.1111/j.1399-3011.1991.tb00729.x