The role of hexamethylmelamine in the management of ovarian cancer

Hexamethylmelamine has been recognized as having useful single-agent activity for the treatment of ovarian cancer for the past 25 years, with some patients surviving disease-free for periods in excess of 12 years. Data from recently analysed and mature trials demonstrate that the addition of hexamet...

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Veröffentlicht in:	Cancer treatment reviews 1991-03, Vol.18, p.67-75
Hauptverfasser:	Schein, Philip S., Scheffler, Barbara, McCulloch, William
Format:	Artikel
Sprache:	eng
Schlagworte:	Altretamine - administration & dosage Altretamine - therapeutic use Antineoplastic agents Antineoplastic Agents - therapeutic use Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Chemotherapy Female Follow-Up Studies Humans Medical sciences Neoplasm Staging Ovarian Neoplasms - drug therapy Ovarian Neoplasms - pathology Pharmacology. Drug treatments
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Zusammenfassung:	Hexamethylmelamine has been recognized as having useful single-agent activity for the treatment of ovarian cancer for the past 25 years, with some patients surviving disease-free for periods in excess of 12 years. Data from recently analysed and mature trials demonstrate that the addition of hexamethylmelamine to first-line combination chemotherapy results in significant improvements in survival compared to what is achieved with regimens of cisplatin and cyclophosphamide with or without doxorubicin.
ISSN:	0305-7372 1532-1967
DOI:	10.1016/0305-7372(91)90026-V