Opiate Antagonists Improve Spatial Memory

Opiate Antagonists Improve Spatial Memory

Rats trained on an eight-arm radial maze were challenged by placing the maze in new spatial environments. Administration of opiate antagonists, either naloxone or diprenorphine, after exposure to the new environments significantly improved subsequent performance. The effect of naloxone on spatial me...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1983-09, Vol.221 (4614), p.975-976
Hauptverfasser: Gallagher, Michela, King, Richard A., Young, Nancy B.
Format: Artikel
Sprache:eng
Schlagworte:
Academic learning
Analgesics
Animal training
Animals
Behavior, Animal
Biological and medical sciences
Brain research
Educational administration
Endorphins
Experimentation
Intravenous injections
Male
Mazes
Medical sciences
Memory
Memory - drug effects
naloxone
Naloxone - pharmacology
Neuropharmacology
Observations
Opiates
Opioid peptides
Pharmacology. Drug treatments
Physiological aspects
Psychopharmacology
Rats
Spatial Behavior
Training
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Zusammenfassung:Rats trained on an eight-arm radial maze were challenged by placing the maze in new spatial environments. Administration of opiate antagonists, either naloxone or diprenorphine, after exposure to the new environments significantly improved subsequent performance. The effect of naloxone on spatial memory was attenuated when drug administration occurred 2 hours after maze exposure.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.6879198