Positively and negatively acting signals regulating stalk cell and anterior-like cell differentiation in dictyostelium
The Dictyostelium ecmB gene encodes an extracellular matrix protein and is inducible by the stalk cell morphogen DIF. It is expressed in a subset of prestalk (pstB) cells in the slug and surrounding pstA cells first express it at culmination. A region of the ecmB promoter can direct transcription in...
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| Veröffentlicht in: | Cell 1991-06, Vol.65 (6), p.983-989 |
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| creator | Ceccarelli, Adriano Mahbubani, Hiro Williams, Jeffrey G. |
| description | The Dictyostelium
ecmB gene encodes an extracellular matrix protein and is inducible by the stalk cell morphogen DIF. It is expressed in a subset of prestalk (pstB) cells in the slug and surrounding pstA cells first express it at culmination. A region of the
ecmB promoter can direct transcription in all anterior prestalk cells, but a separate, downstream region acts to prevent its expression in pstA cells prior to culmination. This may be the site of interaction of a repressor, regulated by an extracellular antagonist to DIF. At culmination, expression of the
ecmB gene also becomes greatly elevated in anterior-like cells as they move to surround the spore mass. A distal region of the
ecmB promoter directs increased expression in those anterior-like cells that surmount the spore head. This divergence in gene expression suggests that anterior-like cells and anterior prestalk cells experience different inductive conditions at culmination. |
| doi_str_mv | 10.1016/0092-8674(91)90550-I |
| format | Article |
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ecmB gene encodes an extracellular matrix protein and is inducible by the stalk cell morphogen DIF. It is expressed in a subset of prestalk (pstB) cells in the slug and surrounding pstA cells first express it at culmination. A region of the
ecmB promoter can direct transcription in all anterior prestalk cells, but a separate, downstream region acts to prevent its expression in pstA cells prior to culmination. This may be the site of interaction of a repressor, regulated by an extracellular antagonist to DIF. At culmination, expression of the
ecmB gene also becomes greatly elevated in anterior-like cells as they move to surround the spore mass. A distal region of the
ecmB promoter directs increased expression in those anterior-like cells that surmount the spore head. This divergence in gene expression suggests that anterior-like cells and anterior prestalk cells experience different inductive conditions at culmination.</description><identifier>ISSN: 0092-8674</identifier><identifier>EISSN: 1097-4172</identifier><identifier>DOI: 10.1016/0092-8674(91)90550-I</identifier><identifier>PMID: 2044155</identifier><identifier>CODEN: CELLB5</identifier><language>eng</language><publisher>Cambridge, MA: Elsevier Inc</publisher><subject>Base Sequence ; Biological and medical sciences ; Cell Differentiation ; Cell differentiation, maturation, development, hematopoiesis ; Cell physiology ; Dictyostelium - cytology ; Dictyostelium - genetics ; DNA Mutational Analysis ; DNA, Fungal - genetics ; Extracellular Matrix Proteins - genetics ; Fundamental and applied biological sciences. Psychology ; Fungal Proteins - genetics ; Gene Expression Regulation, Fungal ; Genes, Fungal ; Molecular and cellular biology ; Molecular Sequence Data ; Morphogenesis ; Promoter Regions, Genetic ; Protozoan Proteins ; Regulatory Sequences, Nucleic Acid ; Restriction Mapping</subject><ispartof>Cell, 1991-06, Vol.65 (6), p.983-989</ispartof><rights>1991</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c535t-65486bf7f41b468e09c98100dd6fbc0ca91cd2060e6dd79305619b1be074cee43</citedby><cites>FETCH-LOGICAL-c535t-65486bf7f41b468e09c98100dd6fbc0ca91cd2060e6dd79305619b1be074cee43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0092-8674(91)90550-I$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19781893$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2044155$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ceccarelli, Adriano</creatorcontrib><creatorcontrib>Mahbubani, Hiro</creatorcontrib><creatorcontrib>Williams, Jeffrey G.</creatorcontrib><title>Positively and negatively acting signals regulating stalk cell and anterior-like cell differentiation in dictyostelium</title><title>Cell</title><addtitle>Cell</addtitle><description>The Dictyostelium
ecmB gene encodes an extracellular matrix protein and is inducible by the stalk cell morphogen DIF. It is expressed in a subset of prestalk (pstB) cells in the slug and surrounding pstA cells first express it at culmination. A region of the
ecmB promoter can direct transcription in all anterior prestalk cells, but a separate, downstream region acts to prevent its expression in pstA cells prior to culmination. This may be the site of interaction of a repressor, regulated by an extracellular antagonist to DIF. At culmination, expression of the
ecmB gene also becomes greatly elevated in anterior-like cells as they move to surround the spore mass. A distal region of the
ecmB promoter directs increased expression in those anterior-like cells that surmount the spore head. This divergence in gene expression suggests that anterior-like cells and anterior prestalk cells experience different inductive conditions at culmination.</description><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Cell Differentiation</subject><subject>Cell differentiation, maturation, development, hematopoiesis</subject><subject>Cell physiology</subject><subject>Dictyostelium - cytology</subject><subject>Dictyostelium - genetics</subject><subject>DNA Mutational Analysis</subject><subject>DNA, Fungal - genetics</subject><subject>Extracellular Matrix Proteins - genetics</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fungal Proteins - genetics</subject><subject>Gene Expression Regulation, Fungal</subject><subject>Genes, Fungal</subject><subject>Molecular and cellular biology</subject><subject>Molecular Sequence Data</subject><subject>Morphogenesis</subject><subject>Promoter Regions, Genetic</subject><subject>Protozoan Proteins</subject><subject>Regulatory Sequences, Nucleic Acid</subject><subject>Restriction Mapping</subject><issn>0092-8674</issn><issn>1097-4172</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9v1DAQxS0EKkvhG4CUCwgOKeOs_16QUAV0pUrlAGfLsScrU69TbGel_fZkm6XcysnyzO89jd4j5DWFCwpUfATQXauEZO81_aCBc2g3T8iKgpYto7J7SlYPyHPyopRfAKA452fkrAPGKOcrsv8-llDDHuOhsck3Cbf279fVkLZNCdtkY2kybqdol1G18bZxGOO9xqaKOYy5jeEWl7EPw4AZUw2zYkxNSPPI1cNYKsYw7V6SZ8Nsiq9O7zn5-fXLj8ur9vrm2-by83Xr-JrXVnCmRD_IgdGeCYWgnVYUwHsx9A6c1dT5DgSg8F7qNXBBdU97BMkcIlufk3eL710ef09YqtmFcrzQJhynYhRwLZnk_wWpANVJQWeQLaDLYykZB3OXw87mg6Fgjr2YY-jmGLrR1Nz3Yjaz7M3Jf-p36B9EpyLm_dvT3hZn45BtcqH889ZSUaXXM_dp4XBObR8wm-ICJoc-ZHTV-DE8fsgfOjar4A</recordid><startdate>19910614</startdate><enddate>19910614</enddate><creator>Ceccarelli, Adriano</creator><creator>Mahbubani, Hiro</creator><creator>Williams, Jeffrey G.</creator><general>Elsevier Inc</general><general>Cell Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19910614</creationdate><title>Positively and negatively acting signals regulating stalk cell and anterior-like cell differentiation in dictyostelium</title><author>Ceccarelli, Adriano ; Mahbubani, Hiro ; Williams, Jeffrey G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c535t-65486bf7f41b468e09c98100dd6fbc0ca91cd2060e6dd79305619b1be074cee43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Cell Differentiation</topic><topic>Cell differentiation, maturation, development, hematopoiesis</topic><topic>Cell physiology</topic><topic>Dictyostelium - cytology</topic><topic>Dictyostelium - genetics</topic><topic>DNA Mutational Analysis</topic><topic>DNA, Fungal - genetics</topic><topic>Extracellular Matrix Proteins - genetics</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fungal Proteins - genetics</topic><topic>Gene Expression Regulation, Fungal</topic><topic>Genes, Fungal</topic><topic>Molecular and cellular biology</topic><topic>Molecular Sequence Data</topic><topic>Morphogenesis</topic><topic>Promoter Regions, Genetic</topic><topic>Protozoan Proteins</topic><topic>Regulatory Sequences, Nucleic Acid</topic><topic>Restriction Mapping</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ceccarelli, Adriano</creatorcontrib><creatorcontrib>Mahbubani, Hiro</creatorcontrib><creatorcontrib>Williams, Jeffrey G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ceccarelli, Adriano</au><au>Mahbubani, Hiro</au><au>Williams, Jeffrey G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Positively and negatively acting signals regulating stalk cell and anterior-like cell differentiation in dictyostelium</atitle><jtitle>Cell</jtitle><addtitle>Cell</addtitle><date>1991-06-14</date><risdate>1991</risdate><volume>65</volume><issue>6</issue><spage>983</spage><epage>989</epage><pages>983-989</pages><issn>0092-8674</issn><eissn>1097-4172</eissn><coden>CELLB5</coden><abstract>The Dictyostelium
ecmB gene encodes an extracellular matrix protein and is inducible by the stalk cell morphogen DIF. It is expressed in a subset of prestalk (pstB) cells in the slug and surrounding pstA cells first express it at culmination. A region of the
ecmB promoter can direct transcription in all anterior prestalk cells, but a separate, downstream region acts to prevent its expression in pstA cells prior to culmination. This may be the site of interaction of a repressor, regulated by an extracellular antagonist to DIF. At culmination, expression of the
ecmB gene also becomes greatly elevated in anterior-like cells as they move to surround the spore mass. A distal region of the
ecmB promoter directs increased expression in those anterior-like cells that surmount the spore head. This divergence in gene expression suggests that anterior-like cells and anterior prestalk cells experience different inductive conditions at culmination.</abstract><cop>Cambridge, MA</cop><pub>Elsevier Inc</pub><pmid>2044155</pmid><doi>10.1016/0092-8674(91)90550-I</doi><tpages>7</tpages></addata></record> |
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| subjects | Base Sequence Biological and medical sciences Cell Differentiation Cell differentiation, maturation, development, hematopoiesis Cell physiology Dictyostelium - cytology Dictyostelium - genetics DNA Mutational Analysis DNA, Fungal - genetics Extracellular Matrix Proteins - genetics Fundamental and applied biological sciences. Psychology Fungal Proteins - genetics Gene Expression Regulation, Fungal Genes, Fungal Molecular and cellular biology Molecular Sequence Data Morphogenesis Promoter Regions, Genetic Protozoan Proteins Regulatory Sequences, Nucleic Acid Restriction Mapping |
| title | Positively and negatively acting signals regulating stalk cell and anterior-like cell differentiation in dictyostelium |
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