Autologous Bone Marrow Transplantation in 69 Patients With a History of Low-Grade B-Cell Non-Hodgkin's Lymphoma
Sixty-nine patients with a history of low-grade B-cell non-Hodgkin's lymphoma (NHL) in sensitive relapse or incomplete first remission underwent high-dose chemoradiotherapy and anti–B-cell monoclonal antibody (MoAb)–treated autologous bone marrow transplantation (ABMT). At ABMT, 51 patients had...
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Veröffentlicht in: | Blood 1991-06, Vol.77 (11), p.2524-2529 |
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Sprache: | eng |
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Zusammenfassung: | Sixty-nine patients with a history of low-grade B-cell non-Hodgkin's lymphoma (NHL) in sensitive relapse or incomplete first remission underwent high-dose chemoradiotherapy and anti–B-cell monoclonal antibody (MoAb)–treated autologous bone marrow transplantation (ABMT). At ABMT, 51 patients had low-grade histology and 18 patients had a history of low-grade NHL that had undergone histologic transformation to a higher-grade NHL. Before ABMT, only 20 of the 51 low-grade patients and 10 of the 18 patients with transformed histologies were in complete remission. Moreover, at the time of marrow harvest, 24 of the low-grade and eight of the transformed histology patients had histologic evidence of lymphoma cells infiltrating the marrow. Following high-dose therapy, only one acute, in-hospital death was observed. There was no significant difference in the disease-free survival (DFS) between patients with low-grade and patients with transformed histologies. Among patients with low-grade NHL, the patients in complete remission before ABMT experienced significantly longer DFS than those in partial remission (P < .05). This preliminary study suggests that some patients with relapsed low-grade NHL may experience prolonged DFS following high-dose ablative therapy. |
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ISSN: | 0006-4971 1528-0020 |
DOI: | 10.1182/blood.V77.11.2524.2524 |