VANOXONIN, A NEW INHIBITOR OF THYMIDYLATE SYNTHETASE

VANOXONIN, A NEW INHIBITOR OF THYMIDYLATE SYNTHETASE

Vanoxonin, a new inhibitor of thymidylate synthetase, was found in cultured broths of the strain MG245-CF2 classified as Saccharopolyspora hirsuta. Vanoxonin, C15H25N3O9, was obtained as colorless powder. Vanoxonin forms a vanadium complex which exhibits a strong inhibition against thymidylate synth...

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Veröffentlicht in:Journal of antibiotics 1983, Vol.36(6), pp.656-660
Hauptverfasser: KANAI, FUMIAKI, SAWA, TSUTOMU, HAMADA, MASA, NAGANAWA, HIROSHI, TAKEUCHI, TOMIO, UMEZAWA, HAMAO
Format: Artikel
Sprache:eng
Schlagworte:
Actinomycetales - analysis
Animals
Carcinoma, Ehrlich Tumor - enzymology
Cations, Divalent
Dipeptides - isolation & purification
Dipeptides - pharmacology
Kinetics
Methyltransferases - antagonists & inhibitors
Mice
Saccharopolyspora hirsuta
Spectrophotometry, Ultraviolet
thymidylate synthase
Thymidylate Synthase - antagonists & inhibitors
tumors
vanoxonin
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Zusammenfassung:Vanoxonin, a new inhibitor of thymidylate synthetase, was found in cultured broths of the strain MG245-CF2 classified as Saccharopolyspora hirsuta. Vanoxonin, C15H25N3O9, was obtained as colorless powder. Vanoxonin forms a vanadium complex which exhibits a strong inhibition against thymidylate synthetase. The concentration for 50%. inhibition of the enzyme (IC50) was 0.7 μg/ml.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.36.656