Genetic mapping of the gene for a novel tyrosine kinase, Blk, to mouse chromosome 14

The gene Blk, which encodes a novel tyrosine kinase expressed preferentially in B-lymphoid cells, was mapped by Southern blot analysis of DNA from the progeny of an intersubspecific backcross. Blk maps to the proximal region of chromosome 14 with the gene order centromere- (Np-1, Tcra)-Blk-sys-Es-10...

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Veröffentlicht in:	Genomics (San Diego, Calif.) Calif.), 1991-04, Vol.9 (4), p.762-764
Hauptverfasser:	Kozak, Christine A., Dymecki, Susan M., Niederhuber, John E., Desiderio, Stephen V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals B-Lymphocytes - metabolism Biological and medical sciences Blotting, Southern Chromosome Mapping Classical genetics, quantitative genetics, hybrids Crosses, Genetic Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Mice Protein-Tyrosine Kinases - genetics Vertebrata
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Beschreibung
Zusammenfassung:	The gene Blk, which encodes a novel tyrosine kinase expressed preferentially in B-lymphoid cells, was mapped by Southern blot analysis of DNA from the progeny of an intersubspecific backcross. Blk maps to the proximal region of chromosome 14 with the gene order centromere- (Np-1, Tcra)-Blk-sys-Es-10.
ISSN:	0888-7543 1089-8646
DOI:	10.1016/0888-7543(91)90372-L