Epoxide hydrolase activity in isolated peroxisomes of mouse liver

Epoxide hydrolase activity in isolated peroxisomes of mouse liver

Using trans-stilbene oxide as substrate, the subcellular distribution of epoxide hydrolase was investigated in livers from DBA/2 mice. The highest specific activities were found in cytosolic and light mitochondrial fractions. Isopycnic subfractionation of the light mitochondrial fraction showed that...

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Veröffentlicht in:FEBS letters 1983-07, Vol.158 (2), p.225-228
Hauptverfasser: Waechter, Felix, Philip, Bentley, Françoise, Bieri, Willy, Stäubli, Alfred, Völkl, Fahimi, Hussein D.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Epoxide hydrolase
Epoxide Hydrolases - metabolism
In Vitro Techniques
Liver - enzymology
Male
Mice
Mice, Inbred DBA
Microbodies - enzymology
Organoids - enzymology
Peroxisome
Stilbenes - metabolism
Subcellular distribution
trans-stilbene oxide
TSO
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Zusammenfassung:Using trans-stilbene oxide as substrate, the subcellular distribution of epoxide hydrolase was investigated in livers from DBA/2 mice. The highest specific activities were found in cytosolic and light mitochondrial fractions. Isopycnic subfractionation of the light mitochondrial fraction showed that the organelle-bound trans-stilbene oxide hydrolase is localized in peroxisomes.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(83)80583-3