Primary Small-Cell Carcinoma of the Esophagus: Report of 11 Cases and Review of the Literature

rimary small-cell carcinoma of the esophagus is an ncommon esophageal malignancy. This report details e clinical and pathologic aspects of 11 cases seen at our stitution over 20 years, as well as 123 other cases ported in the literature. Small-cell carcinomas of the ophagus show considerable histologic heterogeneity, eurosecretory granules can be found in the majority of ses and some show evidence of multidifferentiation. ike primary small-cell cancers of the lung, those in the ophagus are highly aggressive, are usually associated ith spread at the time of diagnosis, and have a dismal ognosis regardless of treatment. The possible origin of is interesting variety of esophageal neoplasm is also scussed.