Inhibition of virus-induced diabetes mellitus by interferon is influenced by the host strain

The diabetogenic variant of encephalomyocarditis virus (EMC-D) induces a diabetes-like syndrome in certain strains of mice. A study was done to determine if virus-induced diabetes could be prevented by interferon (IFN). It was found that the production of diabetes by EMC-D was blocked by either IFN...

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Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 1983-07, Vol.173 (3), p.328-331
Hauptverfasser:	Giron, D J, Cohen, S J, Lyons, S P, Wharton, C H, Cerutis, D R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Diabetes Mellitus - etiology Diabetes Mellitus - genetics Diabetes Mellitus - prevention & control encephalomyocarditis virus Encephalomyocarditis virus - physiology Enterovirus Infections - complications Interferon Inducers - therapeutic use Interferon Type I - therapeutic use Male Mice Mice, Inbred ICR Poly I-C - therapeutic use Virus Replication - drug effects
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Beschreibung
Zusammenfassung:	The diabetogenic variant of encephalomyocarditis virus (EMC-D) induces a diabetes-like syndrome in certain strains of mice. A study was done to determine if virus-induced diabetes could be prevented by interferon (IFN). It was found that the production of diabetes by EMC-D was blocked by either IFN beta or a variety of IFN-inducers in SWR/J, but not ICR Swiss mice. The replication of EMC-D in cell culture was inhibited by IFN beta. It is concluded that the response of pancreatic beta cells to the protective effect of IFN, is probably under genetic control.
ISSN:	0037-9727 1535-3702 1535-3699
DOI:	10.3181/00379727-173-41651