Antispasmodic effect of Hagenia abyssinica

Antispasmodic effect of Hagenia abyssinica

Abstract The water extract of Kosso, (HAGENIA ABYSSINICA, GMELIN) as used in traditional Ethiopian medicine, was tested on the isolated guinea pig ileum employing acetylcholine, histamine and barium chloride as spasmogens. The effect of all three spasmogens was antagonized by Kosso in a concentratio...

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Veröffentlicht in:Planta medica 1983-04, Vol.47 (4), p.240-241
Hauptverfasser: Arragie, M, Metzner, J, Bekemeier, H
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Guinea Pigs
In Vitro Techniques
nonfood plant products
Parasympatholytics
Plant Extracts - pharmacology
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Zusammenfassung:Abstract The water extract of Kosso, (HAGENIA ABYSSINICA, GMELIN) as used in traditional Ethiopian medicine, was tested on the isolated guinea pig ileum employing acetylcholine, histamine and barium chloride as spasmogens. The effect of all three spasmogens was antagonized by Kosso in a concentration range of 0.05-0.2 ml/10 ml of bathing fluid. The mechanism of antagonism was non-competitive. This smooth muscle inhibitory effect might contribute to the taenicidal action of Kosso.
ISSN:0032-0943
1439-0221
DOI:10.1055/s-2007-969997