Protein N-myristoylation

Protein N-myristoylation refers to the co-translational linkage of myristic acid (C14:0) via an amide bond to the NH sub(2)-terminal Gly residues of a variety of eukaryotic cellular and viral proteins. Recent genetic, biochemical organic chemical, molecular, and cell biological studies have yielded...

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Veröffentlicht in:	The Journal of biological chemistry 1991-05, Vol.266 (14), p.8647-8650
Hauptverfasser:	GORDON, J. I, DURONIO, R. J, RUDNICK, D. A, ADAMS, S. P, GOKEL, G. W
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyl Coenzyme A - metabolism Acyltransferases - physiology Animals Biological and medical sciences Cell metabolism, cell oxidation Cell physiology Fundamental and applied biological sciences. Psychology Molecular and cellular biology Myristates - metabolism N-myristoylation Protein Processing, Post-Translational proteins Saccharomyces cerevisiae - enzymology Substrate Specificity
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Beschreibung
Zusammenfassung:	Protein N-myristoylation refers to the co-translational linkage of myristic acid (C14:0) via an amide bond to the NH sub(2)-terminal Gly residues of a variety of eukaryotic cellular and viral proteins. Recent genetic, biochemical organic chemical, molecular, and cell biological studies have yielded (i) a number of insights about how protein N-myristoylation is regulated and (ii) provided strategies for modulating this process in vivo that may have therapeutic implications.
ISSN:	0021-9258 1083-351X
DOI:	10.1016/S0021-9258(18)31490-X