Dopamine depletion in nucleus accumbens reduces ACTH1-24-induced excessive grooming

Animals were pretreated with 6-OHDA or ascorbate vehicle injected into the nucleus accumbens and tested 10 days later for excessive grooming induced by intracerebroventricular injection of ACTH1-24. The animals pretreated with 6-OHDA showed a significant decrease in excessive grooming produced by th...

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Veröffentlicht in:	Life sciences (1973) 1983-07, Vol.33 (3), p.207-211
Hauptverfasser:	Springer, J E, Isaacson, R L, Ryan, J P, Hannigan, Jr, J H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenocorticotropic Hormone - analogs & derivatives Animals Cosyntropin - pharmacology Dopamine - metabolism Grooming - drug effects Hydroxydopamines - pharmacology Male Nucleus Accumbens - drug effects Nucleus Accumbens - metabolism Oxidopamine Rats Rats, Inbred Strains Septal Nuclei - drug effects Time Factors
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Zusammenfassung:	Animals were pretreated with 6-OHDA or ascorbate vehicle injected into the nucleus accumbens and tested 10 days later for excessive grooming induced by intracerebroventricular injection of ACTH1-24. The animals pretreated with 6-OHDA showed a significant decrease in excessive grooming produced by the neuropeptide and this reduction was seen only in the last 30 minutes of a 60-min test session. The results suggest an interaction of ACTH with dopamine systems on the onset and maintenance of excessive grooming.
ISSN:	0024-3205
DOI:	10.1016/0024-3205(83)90378-8