Glutamate Uptake and Metabolism in C‐6 Glioma Cells: Alterations by Potassium Ion and Dibutyryl cAMP

: Uptake and metabolism of glutamate was studied in the C‐6 glioma cell line grown in the absence or presence of dibutyryl cyclic AMP (dbcAMP). Glutamate and aspartate uptake were competitive in cells grown under both conditions. Increased [K+] in the medium caused a significant decrease in the upta...

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Veröffentlicht in:	Journal of neurochemistry 1983-01, Vol.41 (1), p.179-187
Hauptverfasser:	Nicklas, William J., Browning, Edward T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acid uptake Amino Acids - isolation & purification Animals Biological Transport - drug effects Bucladesine - pharmacology Cell Line Chromatography, High Pressure Liquid Cyclic AMP dibutyryl cyclic AMP GABA Glial Cells Glioma - metabolism glioma cells Glutamate Glutamates - metabolism Glutamic Acid Glutamine Glutamine synthetase Kinetics metabolism Neoplasms, Experimental - metabolism potassium Potassium - pharmacology Potassium ion Rats Sodium - pharmacology
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Beschreibung
Zusammenfassung:	: Uptake and metabolism of glutamate was studied in the C‐6 glioma cell line grown in the absence or presence of dibutyryl cyclic AMP (dbcAMP). Glutamate and aspartate uptake were competitive in cells grown under both conditions. Increased [K+] in the medium caused a significant decrease in the uptake of both amino acids. A small part of this decrease (
ISSN:	0022-3042 1471-4159
DOI:	10.1111/j.1471-4159.1983.tb13667.x