Genetic polymorphism of the murine myogenic gene Myo-D1

Polymorphism of the myogenic gene, Myo-D1, has been sought to examine genetic mechanisms which control skeletal muscle development. By Southern analysis, three restriction-fragment length polymorphisms (RFLPs) have been found in various mouse strains using the TaqI, SacI and BglII restriction endonu...

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Veröffentlicht in:	Gene 1991-03, Vol.99 (2), p.273-277
Hauptverfasser:	Kay, Peter H., Jacobsen, Phillip F., Ming-Hao, Zheng, Papadimitriou, John M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Biological and medical sciences Blotting, Southern Chromosomal DNA Classical genetics, quantitative genetics, hybrids DNA - analysis F1, F2 hybrids Fundamental and applied biological sciences. Psychology Gene Rearrangement Genetics of eukaryotes. Biological and molecular evolution linkage disequilibrium Mice Mice, Inbred Strains - genetics Models, Genetic Molecular Sequence Data mouse strains Multigene Family MyoD Protein Nuclear Proteins - genetics phosphoprotein Phosphoproteins - genetics Polymorphism, Genetic Polymorphism, Restriction Fragment Length recombinant DNA restriction endonucleases Southern blotting Trans-Activators - genetics Vertebrata
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Zusammenfassung:	Polymorphism of the myogenic gene, Myo-D1, has been sought to examine genetic mechanisms which control skeletal muscle development. By Southern analysis, three restriction-fragment length polymorphisms (RFLPs) have been found in various mouse strains using the TaqI, SacI and BglII restriction endonucleases and a full-length cDNA Myo-D1 probe. Reference to the distribution of RFLPs in different mouse strains derived from Mus mus (M.m.) domesticus and M.m. musculus subspecies suggests that Myo-D1 rearrangements are subject to nonrandom association. The biological significance ofRFLP of the Myo-D1 gene is yet to be determined.
ISSN:	0378-1119 1879-0038
DOI:	10.1016/0378-1119(91)90138-2