Perioperative chemotherapy in oral cancer

Perioperative chemotherapy in oral cancer

This is an interim report of a study of perioperative adjuvant chemotherapy following radical surgery for oral cancer, based on the hypothesis of Goldie and Coleman. 135 patients of alveolobuccal carcinoma, clinically stage III and IV, were entered on the protocol. After a curative resection, they w...

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Veröffentlicht in:Journal of surgical oncology 1991-05, Vol.47 (1), p.21-26
Hauptverfasser: Rao, Raja S., Parikh, Deepak M., Parikh, Hemen K., Bhansali, Mehul B., Fakih, Abdul R.
Format: Artikel
Sprache:eng
Schlagworte:
adjuvant chemotherapy
Adult
Aged
Biological and medical sciences
Combined Modality Therapy
Humans
Medical sciences
Methotrexate - administration & dosage
Methotrexate - therapeutic use
Middle Aged
Mouth Neoplasms - drug therapy
Mouth Neoplasms - mortality
Mouth Neoplasms - surgery
Neoplasm Recurrence, Local
oral cancer
Otorhinolaryngology. Stomatology
Postoperative Period
Time Factors
timing
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Beschreibung
Zusammenfassung:This is an interim report of a study of perioperative adjuvant chemotherapy following radical surgery for oral cancer, based on the hypothesis of Goldie and Coleman. 135 patients of alveolobuccal carcinoma, clinically stage III and IV, were entered on the protocol. After a curative resection, they were randomized. The test arm received methotrexate 50 mg/m2 on the 3rd, 10th, and 17th postoperative days. The control arm was only observed. This analysis at 12 months showed a disease free survival of 71% in the test arm vs. 45% in the control arm, which is statistically highly significant (P
ISSN:0022-4790
1096-9098
DOI:10.1002/jso.2930470106