Linkage and chromosome study of multiple endocrine neoplasia IIa
A linkage and chromosome investigation of a large family with multiple endocrine neoplasia (MEN) IIa (medullary thyroid carcinoma, pheochromocytoma, and occasionally hyperparathyroidism) was undertaken. No significantly positive lodscores were obtained between MEN IIa and 25 different genetic marker...
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| Veröffentlicht in: | Cancer genetics and cytogenetics 1983-01, Vol.9 (3), p.251-259 |
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| container_title | Cancer genetics and cytogenetics |
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| creator | Emmertsen, Kristian Lamm, Lars Urban Rasmussen, Kirsten Zimmer Elbrønd, Ole Hansen, Hans Hvid Henningsen, Klavs Jørgensen, Jan Petersen, Gert Bruun |
| description | A linkage and chromosome investigation of a large family with multiple endocrine neoplasia (MEN) IIa (medullary thyroid carcinoma, pheochromocytoma, and occasionally hyperparathyroidism) was undertaken. No significantly positive lodscores were obtained between MEN IIa and 25 different genetic markers. Conventional metaphase chromosome analysis showed normal karyotypes and no heterochromatin markers linked to the MEN IIa locus were found. High-resolution chromosome analysis in five MEN IIa carriers revealed no deletion within band 20p12.2. The present investigation could thus neither demonstrate linkage of the MEN IIa locus to genetic or chromosome markers nor identify chromosome abnormalities in MEN IIa carriers. |
| doi_str_mv | 10.1016/0165-4608(83)90009-2 |
| format | Article |
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No significantly positive lodscores were obtained between MEN IIa and 25 different genetic markers. Conventional metaphase chromosome analysis showed normal karyotypes and no heterochromatin markers linked to the MEN IIa locus were found. High-resolution chromosome analysis in five MEN IIa carriers revealed no deletion within band 20p12.2. The present investigation could thus neither demonstrate linkage of the MEN IIa locus to genetic or chromosome markers nor identify chromosome abnormalities in MEN IIa carriers.</description><identifier>ISSN: 0165-4608</identifier><identifier>EISSN: 1873-4456</identifier><identifier>DOI: 10.1016/0165-4608(83)90009-2</identifier><identifier>PMID: 6134579</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aged ; Chromosome Aberrations ; Female ; Genetic Linkage ; Genetic Markers ; Humans ; Karyotyping ; Male ; Middle Aged ; Multiple Endocrine Neoplasia - genetics ; Pedigree</subject><ispartof>Cancer genetics and cytogenetics, 1983-01, Vol.9 (3), p.251-259</ispartof><rights>1983</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-66073b5c3e65647986c5d16ef4a0516190964f188519b24ab0770f795e1d70623</citedby><cites>FETCH-LOGICAL-c388t-66073b5c3e65647986c5d16ef4a0516190964f188519b24ab0770f795e1d70623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0165-4608(83)90009-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6134579$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Emmertsen, Kristian</creatorcontrib><creatorcontrib>Lamm, Lars Urban</creatorcontrib><creatorcontrib>Rasmussen, Kirsten Zimmer</creatorcontrib><creatorcontrib>Elbrønd, Ole</creatorcontrib><creatorcontrib>Hansen, Hans Hvid</creatorcontrib><creatorcontrib>Henningsen, Klavs</creatorcontrib><creatorcontrib>Jørgensen, Jan</creatorcontrib><creatorcontrib>Petersen, Gert Bruun</creatorcontrib><title>Linkage and chromosome study of multiple endocrine neoplasia IIa</title><title>Cancer genetics and cytogenetics</title><addtitle>Cancer Genet Cytogenet</addtitle><description>A linkage and chromosome investigation of a large family with multiple endocrine neoplasia (MEN) IIa (medullary thyroid carcinoma, pheochromocytoma, and occasionally hyperparathyroidism) was undertaken. No significantly positive lodscores were obtained between MEN IIa and 25 different genetic markers. Conventional metaphase chromosome analysis showed normal karyotypes and no heterochromatin markers linked to the MEN IIa locus were found. High-resolution chromosome analysis in five MEN IIa carriers revealed no deletion within band 20p12.2. The present investigation could thus neither demonstrate linkage of the MEN IIa locus to genetic or chromosome markers nor identify chromosome abnormalities in MEN IIa carriers.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Chromosome Aberrations</subject><subject>Female</subject><subject>Genetic Linkage</subject><subject>Genetic Markers</subject><subject>Humans</subject><subject>Karyotyping</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multiple Endocrine Neoplasia - genetics</subject><subject>Pedigree</subject><issn>0165-4608</issn><issn>1873-4456</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkD1PwzAQhi0EKqXwD0DKhGAI2PH3gkAVH5UqscBsuc4FDElc7ASp_56UVh1hON1wz929ehA6JfiKYCKuh-I5E1hdKHqpMcY6L_bQmChJc8a42EfjHXKIjlL6GBhZaDFCI0Eo41KP0e3ct5_2DTLblpl7j6EJKTSQpa4vV1mosqavO7-sIYO2DC76FrIWwrK2ydtsNrPH6KCydYKTbZ-g14f7l-lTPn9-nE3v5rmjSnW5EFjSBXcUBBdMaiUcL4mAilnMiSAaa8EqohQnelEwu8BS4kpqDqSUWBR0gs43d5cxfPWQOtP45KCu7RCnT0ZhXnBB9b8goUJSQvAAsg3oYkgpQmWW0Tc2rgzBZm3YrPWZtT6jqPk1bNZBzrb3-0UD5W5pq3SY32zmMNj49hBNch5aB6WP4DpTBv_3gx-qcYfN</recordid><startdate>19830101</startdate><enddate>19830101</enddate><creator>Emmertsen, Kristian</creator><creator>Lamm, Lars Urban</creator><creator>Rasmussen, Kirsten Zimmer</creator><creator>Elbrønd, Ole</creator><creator>Hansen, Hans Hvid</creator><creator>Henningsen, Klavs</creator><creator>Jørgensen, Jan</creator><creator>Petersen, Gert Bruun</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19830101</creationdate><title>Linkage and chromosome study of multiple endocrine neoplasia IIa</title><author>Emmertsen, Kristian ; Lamm, Lars Urban ; Rasmussen, Kirsten Zimmer ; Elbrønd, Ole ; Hansen, Hans Hvid ; Henningsen, Klavs ; Jørgensen, Jan ; Petersen, Gert Bruun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-66073b5c3e65647986c5d16ef4a0516190964f188519b24ab0770f795e1d70623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Chromosome Aberrations</topic><topic>Female</topic><topic>Genetic Linkage</topic><topic>Genetic Markers</topic><topic>Humans</topic><topic>Karyotyping</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multiple Endocrine Neoplasia - genetics</topic><topic>Pedigree</topic><toplevel>online_resources</toplevel><creatorcontrib>Emmertsen, Kristian</creatorcontrib><creatorcontrib>Lamm, Lars Urban</creatorcontrib><creatorcontrib>Rasmussen, Kirsten Zimmer</creatorcontrib><creatorcontrib>Elbrønd, Ole</creatorcontrib><creatorcontrib>Hansen, Hans Hvid</creatorcontrib><creatorcontrib>Henningsen, Klavs</creatorcontrib><creatorcontrib>Jørgensen, Jan</creatorcontrib><creatorcontrib>Petersen, Gert Bruun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer genetics and cytogenetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Emmertsen, Kristian</au><au>Lamm, Lars Urban</au><au>Rasmussen, Kirsten Zimmer</au><au>Elbrønd, Ole</au><au>Hansen, Hans Hvid</au><au>Henningsen, Klavs</au><au>Jørgensen, Jan</au><au>Petersen, Gert Bruun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Linkage and chromosome study of multiple endocrine neoplasia IIa</atitle><jtitle>Cancer genetics and cytogenetics</jtitle><addtitle>Cancer Genet Cytogenet</addtitle><date>1983-01-01</date><risdate>1983</risdate><volume>9</volume><issue>3</issue><spage>251</spage><epage>259</epage><pages>251-259</pages><issn>0165-4608</issn><eissn>1873-4456</eissn><abstract>A linkage and chromosome investigation of a large family with multiple endocrine neoplasia (MEN) IIa (medullary thyroid carcinoma, pheochromocytoma, and occasionally hyperparathyroidism) was undertaken. 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| ispartof | Cancer genetics and cytogenetics, 1983-01, Vol.9 (3), p.251-259 |
| issn | 0165-4608 1873-4456 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adolescent Adult Aged Chromosome Aberrations Female Genetic Linkage Genetic Markers Humans Karyotyping Male Middle Aged Multiple Endocrine Neoplasia - genetics Pedigree |
| title | Linkage and chromosome study of multiple endocrine neoplasia IIa |
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