Linkage and chromosome study of multiple endocrine neoplasia IIa

A linkage and chromosome investigation of a large family with multiple endocrine neoplasia (MEN) IIa (medullary thyroid carcinoma, pheochromocytoma, and occasionally hyperparathyroidism) was undertaken. No significantly positive lodscores were obtained between MEN IIa and 25 different genetic marker...

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Veröffentlicht in:	Cancer genetics and cytogenetics 1983-01, Vol.9 (3), p.251-259
Hauptverfasser:	Emmertsen, Kristian, Lamm, Lars Urban, Rasmussen, Kirsten Zimmer, Elbrønd, Ole, Hansen, Hans Hvid, Henningsen, Klavs, Jørgensen, Jan, Petersen, Gert Bruun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Chromosome Aberrations Female Genetic Linkage Genetic Markers Humans Karyotyping Male Middle Aged Multiple Endocrine Neoplasia - genetics Pedigree
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Beschreibung
Zusammenfassung:	A linkage and chromosome investigation of a large family with multiple endocrine neoplasia (MEN) IIa (medullary thyroid carcinoma, pheochromocytoma, and occasionally hyperparathyroidism) was undertaken. No significantly positive lodscores were obtained between MEN IIa and 25 different genetic markers. Conventional metaphase chromosome analysis showed normal karyotypes and no heterochromatin markers linked to the MEN IIa locus were found. High-resolution chromosome analysis in five MEN IIa carriers revealed no deletion within band 20p12.2. The present investigation could thus neither demonstrate linkage of the MEN IIa locus to genetic or chromosome markers nor identify chromosome abnormalities in MEN IIa carriers.
ISSN:	0165-4608 1873-4456
DOI:	10.1016/0165-4608(83)90009-2