Brain 5-hydroxytryptamine and learned resistance to punishment

Rats can learn to persist in making a response that is punished. Brain 5-hydroxytryptamine (5-HT) systems are known to mediate acute responding to punishment. This work investigates 5-HT involvement in learned resistance to punishment. Forebrain 5-HT was depleted by intracerebral injection of 5,7-di...

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Veröffentlicht in:	Behavioural brain research 1983-01, Vol.8 (2), p.129-137
Hauptverfasser:	Davis, Nicola M., Gray, Jeffrey A.
Format:	Artikel
Sprache:	eng
Schlagworte:	5,7-Dihydroxytryptamine - pharmacology 5-hydroxytryptamine Animals Avoidance Learning - physiology Brain - physiology Desipramine - pharmacology Electroshock Habituation, Psychophysiologic - physiology Hippocampus - drug effects Male Motivation - physiology Neural Pathways - drug effects partial punishment effect punishment Raphe Nuclei - drug effects rat Rats Rats, Inbred Strains Septum Pellucidum - drug effects Serotonin - physiology Tegmentum Mesencephali - drug effects
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Beschreibung
Zusammenfassung:	Rats can learn to persist in making a response that is punished. Brain 5-hydroxytryptamine (5-HT) systems are known to mediate acute responding to punishment. This work investigates 5-HT involvement in learned resistance to punishment. Forebrain 5-HT was depleted by intracerebral injection of 5,7-dihydroxy-tryptamine. Lesioned rats were fully able to learn resistance to punishment, although acute responding to punishment was impaired. Forebrain 5-HT does not mediate learned resistance to punishment.
ISSN:	0166-4328 1872-7549
DOI:	10.1016/0166-4328(83)90049-9