Expression of the homeobox Hox-4 genes and the specification of position in chick wing development
The chicken Hox-4 homeogenes, like those of the mouse, are coordinately expressed in partially overlapping domains during wing development. Local application of retinoic acid, a putative endogenous morphogen, induces de novo transcription of Hox-4 genes. The mirror-image patterns of Hox-4 gene expre...
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| Veröffentlicht in: | Nature (London) 1991-04, Vol.350 (6319), p.585-589 |
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| creator | Izpisua-Belmonte, J.C Tickle, C Dolle, P Wolpert, L Duboule, D |
| description | The chicken Hox-4 homeogenes, like those of the mouse, are coordinately expressed in partially overlapping domains during wing development. Local application of retinoic acid, a putative endogenous morphogen, induces de novo transcription of Hox-4 genes. The mirror-image patterns of Hox-4 gene expression, which are obtained in this way, correlate with the subsequent development of mirror-image patterns of digits. Hox-4 genes probably encode positional information. |
| doi_str_mv | 10.1038/350585a0 |
| format | Article |
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Local application of retinoic acid, a putative endogenous morphogen, induces de novo transcription of Hox-4 genes. The mirror-image patterns of Hox-4 gene expression, which are obtained in this way, correlate with the subsequent development of mirror-image patterns of digits. Hox-4 genes probably encode positional information.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/350585a0</identifier><identifier>PMID: 1673231</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing</publisher><subject>Amino Acid Sequence ; Animals ; Biological and medical sciences ; biological development ; Birds ; Cellular biology ; Chick Embryo ; Chickens ; chicks ; Cloning, Molecular ; Extremities - embryology ; Fundamental and applied biological sciences. Psychology ; Gene expression ; Gene Expression - drug effects ; Gene Library ; Genes, Homeobox ; Genetics ; Mice ; Molecular and cellular biology ; Molecular genetics ; Molecular Sequence Data ; Physical growth ; retinoic acid ; Sequence Homology, Nucleic Acid ; Tretinoin - pharmacology ; wings ; Wings, Animal - embryology</subject><ispartof>Nature (London), 1991-04, Vol.350 (6319), p.585-589</ispartof><rights>1991 INIST-CNRS</rights><rights>Copyright Macmillan Journals Ltd. 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Local application of retinoic acid, a putative endogenous morphogen, induces de novo transcription of Hox-4 genes. The mirror-image patterns of Hox-4 gene expression, which are obtained in this way, correlate with the subsequent development of mirror-image patterns of digits. Hox-4 genes probably encode positional information.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>biological development</subject><subject>Birds</subject><subject>Cellular biology</subject><subject>Chick Embryo</subject><subject>Chickens</subject><subject>chicks</subject><subject>Cloning, Molecular</subject><subject>Extremities - embryology</subject><subject>Fundamental and applied biological sciences. 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Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Izpisua-Belmonte, J.C</au><au>Tickle, C</au><au>Dolle, P</au><au>Wolpert, L</au><au>Duboule, D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of the homeobox Hox-4 genes and the specification of position in chick wing development</atitle><jtitle>Nature (London)</jtitle><addtitle>Nature</addtitle><date>1991-04-18</date><risdate>1991</risdate><volume>350</volume><issue>6319</issue><spage>585</spage><epage>589</epage><pages>585-589</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><coden>NATUAS</coden><abstract>The chicken Hox-4 homeogenes, like those of the mouse, are coordinately expressed in partially overlapping domains during wing development. Local application of retinoic acid, a putative endogenous morphogen, induces de novo transcription of Hox-4 genes. The mirror-image patterns of Hox-4 gene expression, which are obtained in this way, correlate with the subsequent development of mirror-image patterns of digits. Hox-4 genes probably encode positional information.</abstract><cop>London</cop><pub>Nature Publishing</pub><pmid>1673231</pmid><doi>10.1038/350585a0</doi><tpages>5</tpages></addata></record> |
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| ispartof | Nature (London), 1991-04, Vol.350 (6319), p.585-589 |
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| subjects | Amino Acid Sequence Animals Biological and medical sciences biological development Birds Cellular biology Chick Embryo Chickens chicks Cloning, Molecular Extremities - embryology Fundamental and applied biological sciences. Psychology Gene expression Gene Expression - drug effects Gene Library Genes, Homeobox Genetics Mice Molecular and cellular biology Molecular genetics Molecular Sequence Data Physical growth retinoic acid Sequence Homology, Nucleic Acid Tretinoin - pharmacology wings Wings, Animal - embryology |
| title | Expression of the homeobox Hox-4 genes and the specification of position in chick wing development |
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