Expression of the homeobox Hox-4 genes and the specification of position in chick wing development

The chicken Hox-4 homeogenes, like those of the mouse, are coordinately expressed in partially overlapping domains during wing development. Local application of retinoic acid, a putative endogenous morphogen, induces de novo transcription of Hox-4 genes. The mirror-image patterns of Hox-4 gene expre...

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Veröffentlicht in:	Nature (London) 1991-04, Vol.350 (6319), p.585-589
Hauptverfasser:	Izpisua-Belmonte, J.C, Tickle, C, Dolle, P, Wolpert, L, Duboule, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Biological and medical sciences biological development Birds Cellular biology Chick Embryo Chickens chicks Cloning, Molecular Extremities - embryology Fundamental and applied biological sciences. Psychology Gene expression Gene Expression - drug effects Gene Library Genes, Homeobox Genetics Mice Molecular and cellular biology Molecular genetics Molecular Sequence Data Physical growth retinoic acid Sequence Homology, Nucleic Acid Tretinoin - pharmacology wings Wings, Animal - embryology
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Beschreibung
Zusammenfassung:	The chicken Hox-4 homeogenes, like those of the mouse, are coordinately expressed in partially overlapping domains during wing development. Local application of retinoic acid, a putative endogenous morphogen, induces de novo transcription of Hox-4 genes. The mirror-image patterns of Hox-4 gene expression, which are obtained in this way, correlate with the subsequent development of mirror-image patterns of digits. Hox-4 genes probably encode positional information.
ISSN:	0028-0836 1476-4687
DOI:	10.1038/350585a0