Neuromuscular blocking action of atracurium in the dog and its reversal by neostigmine

The drug, atracurium besylate is one of a new series of competitive muscle relaxants. Doses of 0.2, 0.4 and 0.6 mg/kg produced neuromuscular block in the anaesthetised dog with no cardiovascular effects. The neuromuscular block was readily reversible by neostigmine.

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Bibliographische Detailangaben
Veröffentlicht in:	Research in veterinary science 1983-03, Vol.34 (2), p.173-176
Hauptverfasser:	Jones, R.S., Hunter, J.M., Utting, J.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atracurium Blood Pressure - drug effects Dogs Heart Rate - drug effects Humans Isoquinolines - administration & dosage Isoquinolines - antagonists & inhibitors Isoquinolines - pharmacology Neostigmine - pharmacology Neuromuscular Blocking Agents - administration & dosage Neuromuscular Blocking Agents - antagonists & inhibitors Neuromuscular Blocking Agents - pharmacology
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Beschreibung
Zusammenfassung:	The drug, atracurium besylate is one of a new series of competitive muscle relaxants. Doses of 0.2, 0.4 and 0.6 mg/kg produced neuromuscular block in the anaesthetised dog with no cardiovascular effects. The neuromuscular block was readily reversible by neostigmine.
ISSN:	0034-5288 1532-2661
DOI:	10.1016/S0034-5288(18)32255-0