Effect of prostaglandins on Fc-IgG receptors of human circulating T and B lymphocytes

A short preincubation of human T and B lymphocyte subpopulations with physiologic or pharmacologic concentrations of PGs E2 and F1α but not with E1 and F2α markedly depresses the cell ability to bind immune complexes, through FcR-IgG. This effect appears to be relatively temperature-independent. These observations Indicate that PG treatment of human lymphocytes may be useful to distinguish the subclasses of FcR-IgG-bearing T and B cells, which are sensible to the modulating effect of PGs.