CHEMICAL MODIFICATION OF CARBAPENEM ANTIBIOTICS: VERSATILE METHODS FOR DISPLACEMENT OF THE C-3 SULFUR SIDE CHAIN OF CARBAPENEMS WITH OTHER THIOL GROUPS

Carbapenem derivatives substituted at the C-3 position were synthesized (1) by treating carbapenem S-oxides with various mercaptans in the presence of a base (Fig. 3), or (2) by alkylating or acylating 3-thiol carbapenems (Fig. 4).

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of antibiotics 1983, Vol.36(4), pp.407-415
Hauptverfasser:	YAMAMOTO, KEN-ICHI, YOSHIOKA, TAKEO, KATO, YASUYUKI, ISSHIKI, KUNIO, NISHINO, MASAYOSHI, NAKAMURA, FUJIO, SHIMAUCHI, YASUTAKA, ISHIKURA, TOMOYUKI
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Structure-Activity Relationship Thienamycins - pharmacology
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Carbapenem derivatives substituted at the C-3 position were synthesized (1) by treating carbapenem S-oxides with various mercaptans in the presence of a base (Fig. 3), or (2) by alkylating or acylating 3-thiol carbapenems (Fig. 4).
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.36.407