The high performance liquid chromatographic measurement of chloramphenicol and its succinate esters in serum

The high performance liquid chromatographic measurement of chloramphenicol and its succinate esters in serum

We describe a reliable HPLC procedure for the simultaneous measurement of chloramphenicol and its succinate esters in 30 μL of serum or plasma. The procedure has been applied to assess both the optimum dosing regimen and clinical pharmacokinetics in premature infants.

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Bibliographische Detailangaben
Veröffentlicht in:Clinical biochemistry 1983-06, Vol.16 (3), p.171-177
Hauptverfasser: Soldin, S.J., Golas, C., Rajchgot, P., Prober, C.G., MacLeod, S.M.
Format: Artikel
Sprache:eng
Schlagworte:
Chloramphenicol - analogs & derivatives
Chloramphenicol - blood
Chromatography, High Pressure Liquid
Humans
Infant, Newborn
Infant, Premature
Kinetics
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Beschreibung
Zusammenfassung:We describe a reliable HPLC procedure for the simultaneous measurement of chloramphenicol and its succinate esters in 30 μL of serum or plasma. The procedure has been applied to assess both the optimum dosing regimen and clinical pharmacokinetics in premature infants.
ISSN:0009-9120
1873-2933
DOI:10.1016/S0009-9120(83)90219-9