Stimulus-dependent changes in calcium metabolism in rabbit neutrophils

We have found that the changes in calcium metabolism in rabbit neutrophils produced by the chemotactic synthetic peptide f-Met-Leu-Phe are not sensitive to the calcium chelator EGTA. The present results demonstrate unambiguously that the previously described chemotactic factor induced changes in 45C...

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Veröffentlicht in:	Cell calcium (Edinburgh) 1983-01, Vol.4 (1), p.57-68
Hauptverfasser:	Molski, T.F.P., Naccache, P.H., Sha'afi, R.I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium - blood Calcium Radioisotopes Chemotactic Factors - pharmacology Egtazic Acid - pharmacology In Vitro Techniques N-Formylmethionine - analogs & derivatives N-Formylmethionine - pharmacology N-Formylmethionine Leucyl-Phenylalanine Neutrophils - drug effects Neutrophils - metabolism Oligopeptides - pharmacology Rabbits
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Beschreibung
Zusammenfassung:	We have found that the changes in calcium metabolism in rabbit neutrophils produced by the chemotactic synthetic peptide f-Met-Leu-Phe are not sensitive to the calcium chelator EGTA. The present results demonstrate unambiguously that the previously described chemotactic factor induced changes in 45Ca fluxes in rabbit neutrophils do indeed reflect intracellular events. The pool of calcium mobilized by f-Met-Leu-Phe and increase in cell associated 45Ca upon stimulation are both insensitive to the presence of EGTA.
ISSN:	0143-4160 1532-1991
DOI:	10.1016/0143-4160(83)90049-0