A new method for the determination of steroid sulphatase activity in leukocytes in X-linked recessive ichthyosis

A new method for the determination of steroid sulphatase activity in leukocytes in X-linked recessive ichthyosis

SUMMARY The diagnosis of X‐linked ichthyosis can now be reliably established by using a non‐radioactive method to detect steroid sulphatase deficiency in leukocytes. This new method yields the same results with leukocytes as with cultured fibroblasts. The second type of microsomal arylsulphatase pre...

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Veröffentlicht in:British journal of dermatology (1951) 1983-05, Vol.108 (5), p.567-572
Hauptverfasser: JÖBSIS, A.C., de GROOT, W.P., MEIJER, A.E.F.H., VAN DER LOOS, C.M.
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Aged
Blood Chemical Analysis - methods
Child
Electrophoresis, Polyacrylamide Gel
Female
Genes, Recessive
Humans
Ichthyosis - blood
Ichthyosis - genetics
Leukocytes - enzymology
Male
Middle Aged
Steryl-Sulfatase
Sulfatases - metabolism
X Chromosome
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Zusammenfassung:SUMMARY The diagnosis of X‐linked ichthyosis can now be reliably established by using a non‐radioactive method to detect steroid sulphatase deficiency in leukocytes. This new method yields the same results with leukocytes as with cultured fibroblasts. The second type of microsomal arylsulphatase previously described in cultured fibroblasts is also present in leukocytes.
ISSN:0007-0963
1365-2133
DOI:10.1111/j.1365-2133.1983.tb01058.x