Ontogeny of immunoreactive CCK, VIP and secretin in rat brain and gut

Immunoreactive cholecystokinin (iCCK), vasoactive intestinal peptide (iVIP) and secretin (iSEC) were determined in the brain and various gut regions in the developing rat between 3 and 28 days after birth and in the adult. From the different patterns observed with these three peptides, it is conclud...

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Veröffentlicht in:	Biochemical and biophysical research communications 1983-05, Vol.112 (3), p.891-898
Hauptverfasser:	Ichihara, Kiyoshi, Eng, John, Yalow, Rosalyn S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals Brain - growth & development Brain Chemistry Cholecystokinin - isolation & purification Digestive System - analysis Digestive System - growth & development Gastrointestinal Hormones - isolation & purification Radioimmunoassay Rats Rats, Inbred Strains Secretin - isolation & purification Vasoactive Intestinal Peptide - isolation & purification
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Zusammenfassung:	Immunoreactive cholecystokinin (iCCK), vasoactive intestinal peptide (iVIP) and secretin (iSEC) were determined in the brain and various gut regions in the developing rat between 3 and 28 days after birth and in the adult. From the different patterns observed with these three peptides, it is concluded that in rat neural tissues, peptide concentrations (iCCK in brain, iVIP in brain and gut) increase continuously until about 4 weeks. Concentrations in mucosal tissues (iSEC in gut) are equal to or higher than adult values 3 days after birth. Gut iCCK (found both in neuronal and mucosal tissues) peaks at about 2 weeks, presumably due to concentrations increasing in the former and decreasing in the latter tissues.
ISSN:	0006-291X 1090-2104
DOI:	10.1016/0006-291X(83)91701-1