Lithium and the prevention of dopamine receptor supersensitivity in diabetic rats

Dopamine receptors were increased in rats made diabetic by alloxan; however, chronic lithium treatment substantially reduced the number of dopamine receptors. These findings may be relevant to the effects of lithium in psychiatric disorders.

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Bibliographische Detailangaben
Veröffentlicht in:	The American journal of psychiatry 1983-05, Vol.140 (5), p.613-614
Hauptverfasser:	Lozovsky, D, Saller, C F, Kopin, I J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Glucose - analysis Chlorides - pharmacology Corpus Striatum - metabolism desensitization diabetes mellitus Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - metabolism dopamine lithium Lithium - pharmacology Lithium Chloride Rats Receptors, Dopamine - drug effects Receptors, Dopamine - metabolism Spiperone - metabolism striate cortex
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Beschreibung
Zusammenfassung:	Dopamine receptors were increased in rats made diabetic by alloxan; however, chronic lithium treatment substantially reduced the number of dopamine receptors. These findings may be relevant to the effects of lithium in psychiatric disorders.
ISSN:	0002-953X 1535-7228
DOI:	10.1176/ajp.140.5.613