Receptor for ATP in the membrane of mammalian sensory neurones

Receptor for ATP in the membrane of mammalian sensory neurones

ATP-activated conductance has been found in a large number of neurones isolated from various sensory ganglia of the rat and cat. The inward current produced by ATP ( K d = 5 · 10 −6 M) is carried by cations and demonstrates rapid activation and slow desensitization. The sequence of agonists (ATP >...

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Veröffentlicht in:Neuroscience letters 1983-01, Vol.35 (1), p.41-45
Hauptverfasser: Krishtal, O.A., Marchenko, S.M., Pidoplichko, V.I.
Format: Artikel
Sprache:eng
Schlagworte:
Adenosine Triphosphate - pharmacology
Adenosine Triphosphate - physiology
Animals
ATP
Cations, Divalent - metabolism
Cats
Cell Membrane - analysis
Cell Membrane Permeability
desensitization
Dose-Response Relationship, Drug
Electric Conductivity
intracellular perfusion
Ion Exchange
membrane conductance
Neurons, Afferent - analysis
Neurons, Afferent - physiology
Rats
receptors
Receptors, Cell Surface - analysis
Receptors, Cell Surface - physiology
Receptors, Purinergic
sensory neurons
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Zusammenfassung:ATP-activated conductance has been found in a large number of neurones isolated from various sensory ganglia of the rat and cat. The inward current produced by ATP ( K d = 5 · 10 −6 M) is carried by cations and demonstrates rapid activation and slow desensitization. The sequence of agonists (ATP > ADP) with AMP and adenosine ineffective) is different from those previously described for purinergic receptors P 1 and P 2.
ISSN:0304-3940
1872-7972
DOI:10.1016/0304-3940(83)90524-4