Steroid binding to synaptic plasma membrane: Differential binding of glucocorticoids and gonadal steroids

The specific binding of [ 3H]-corticosterone, [ 3H]-17β-estradiol, [ 3H]-testosterone, and [ 3H]-progesterone to synaptic plasma membrane (SPM) prepared from rat brain has been characterized. The dissociation constant is estimated as on the order of 1 × 10 −7 M for corticosterone and 1 × 10 −8 M for...

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