High Density Lipoprotein Turnover in Patients With Hypertension

Although hyperinsulinemia and decreased high density lipoprotein cholesterol concentration can occur in patients with hypertension, there is no information available concerning the dynamic state of high density lipoprotein metabolism. To address this issue, we quantified high density lipoprotein tur...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 1991-03, Vol.17 (3), p.386-393
Hauptverfasser:	Chen, Y-D Ida, Sheu, Wayne H-H, Swislocki, Arthur L.M, Reaven, Gerald M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Apolipoprotein A-I Apolipoproteins A - blood Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cholesterol, HDL - blood Clinical manifestations. Epidemiology. Investigative techniques. Etiology Female Humans Hypertension - metabolism Hypertriglyceridemia - metabolism Insulin - blood Lipoproteins, HDL - metabolism Male Medical sciences Middle Aged
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Zusammenfassung:	Although hyperinsulinemia and decreased high density lipoprotein cholesterol concentration can occur in patients with hypertension, there is no information available concerning the dynamic state of high density lipoprotein metabolism. To address this issue, we quantified high density lipoprotein turnover in 12 patients with mild hypertension and 11 matched subjects with normal blood pressure. Patients with high blood pressure had lower high density lipoprotein cholesterol concentrations. Fractional catabolic rates of I-apolipoprotein AI (apoAI)/high density lipoprotein were faster in patients with hypertension (0.36±0.02 versus 0.26±0.02 I/day, p
ISSN:	0194-911X 1524-4563
DOI:	10.1161/01.HYP.17.3.386