The relationship between nuclear glutathione levels and resistance to melphalan in human ovarian tumour cells

Endogenous levels of thiols, such as glutathione (GSH), have been suggested as important determinants of the response of cultured human tumour cells to various chemotherapeutic agents, including alkylating agents, platinating agents and anthracyclines. In this study, the relative importance of the n...

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Veröffentlicht in:	Biochemical pharmacology 1991-02, Vol.41 (4), p.647-649
Hauptverfasser:	Britten, R.A., Green, J.A., Broughton, C., Browning, P.G.W., White, R., Warenius, H.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences Buthionine Sulfoximine Cell Nucleus - chemistry Drug Resistance Female General aspects Glutathione - analysis Humans Medical sciences melphalan Melphalan - pharmacology Methionine Sulfoximine - analogs & derivatives Methionine Sulfoximine - pharmacology Ovarian Neoplasms - chemistry Ovarian Neoplasms - pathology ovary Pharmacology. Drug treatments Tumor Cells, Cultured - drug effects
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Zusammenfassung:	Endogenous levels of thiols, such as glutathione (GSH), have been suggested as important determinants of the response of cultured human tumour cells to various chemotherapeutic agents, including alkylating agents, platinating agents and anthracyclines. In this study, the relative importance of the nuclear and cytoplasmic thiol pools in determining the chemosensitivity of the human ovarian adenocarcinoma OAW42 cell line, and the melphalan-resistant (OAW42/MER) subline was examined.
ISSN:	0006-2952 1873-2968
DOI:	10.1016/0006-2952(91)90642-I