Endothelial cells are a site of uptake and degradation of hyaluronic acid in the liver

In a recent communication it was shown that intravenously injected radioactively labelled hyaluronic acid was preferentially taken up by the liver and degraded. We now report that uptake occurs in the liver endothelial cells and that these cells degrade the polysaccharide in vitro into low-molecular...

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Veröffentlicht in:	Experimental cell research 1983-03, Vol.144 (1), p.223-228
Hauptverfasser:	Eriksson, Sigbritt, Fraser, J.Robert E., Laurent, Torvard C., Pertoft, Håkan, Smedsrød, Bård
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell metabolism, cell oxidation Cell physiology Cells, Cultured Endothelium - cytology Endothelium - metabolism Fundamental and applied biological sciences. Psychology Hyaluronic Acid - metabolism Liver - cytology Liver - metabolism Molecular and cellular biology Rats
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Beschreibung
Zusammenfassung:	In a recent communication it was shown that intravenously injected radioactively labelled hyaluronic acid was preferentially taken up by the liver and degraded. We now report that uptake occurs in the liver endothelial cells and that these cells degrade the polysaccharide in vitro into low-molecular weight (LMW) products.
ISSN:	0014-4827 1090-2422
DOI:	10.1016/0014-4827(83)90458-5