Helper‐suppressor T‐cell leukemia: Unusual phenotype controlled with low‐dose deoxycoformycin

Presented is an unusual case of chronic T‐cell leukemia. Immunophenotypic profile revealed the leukemia cells to express T4 and T8 surface markers simultaneously. The patient was treated with low‐dose deoxycoformycin and control of symptoms and lymphocyte levels shown to correlate with ADA and dATP/...

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Veröffentlicht in:	American journal of hematology 1991-03, Vol.36 (3), p.208-210
Hauptverfasser:	Adler, Mark J., Hershberg, Robert, Yu, Alice
Format:	Artikel
Sprache:	eng
Schlagworte:	adenosine deaminase Adenosine Deaminase - metabolism Adenosine Triphosphate - metabolism Adult Antigens, Surface - immunology Biological and medical sciences deoxycoformycin Dose-Response Relationship, Drug Hematologic and hematopoietic diseases Humans Immunophenotyping leukemia Leukemia, T-Cell - drug therapy Leukemia, T-Cell - genetics Leukemia, T-Cell - immunology Leukemia, T-Cell - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Pentostatin - administration & dosage Pentostatin - therapeutic use T-Lymphocytes, Helper-Inducer - enzymology T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Helper-Inducer - pathology T-Lymphocytes, Regulatory - enzymology T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - pathology T‐cell
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Zusammenfassung:	Presented is an unusual case of chronic T‐cell leukemia. Immunophenotypic profile revealed the leukemia cells to express T4 and T8 surface markers simultaneously. The patient was treated with low‐dose deoxycoformycin and control of symptoms and lymphocyte levels shown to correlate with ADA and dATP/ATP levels.
ISSN:	0361-8609 1096-8652
DOI:	10.1002/ajh.2830360310