Effect of beta agonists on protein turnover in adipose tissue

Chronic administration (21 days) of the beta agonist cimaterol to rats decreased epididymal fat by 27%, and inhibited in vitro rates of protein synthesis by 34% and net protein breakdown by 71% in adipose tissue. Likewise, incubation of rat adipose tissue with cimaterol and isoproterenol stimulated...

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Veröffentlicht in:	Life sciences (1973) 1991, Vol.48 (2), p.143-148
Hauptverfasser:	Rogers, Kendra L., Fagan, Julie M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - anatomy & histology Adipose Tissue - drug effects Adipose Tissue - metabolism Administration, Oral Adrenergic beta-Agonists - pharmacology Animals Biological and medical sciences Culture Techniques Epididymis - drug effects Epididymis - metabolism Ethanolamines - administration & dosage Ethanolamines - pharmacology Fundamental and applied biological sciences. Psychology Kinetics Male Proteins - metabolism Rats Rats, Inbred Strains Vertebrates: skin, associated glands, phaneres, light organs, various exocrine glands (salt gland, uropygial gland...), adipose tissue, connective tissue
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Zusammenfassung:	Chronic administration (21 days) of the beta agonist cimaterol to rats decreased epididymal fat by 27%, and inhibited in vitro rates of protein synthesis by 34% and net protein breakdown by 71% in adipose tissue. Likewise, incubation of rat adipose tissue with cimaterol and isoproterenol stimulated lipolysis, and inhibited protein synthesis and degradation. Thus, in addition to affecting muscle mass and lipid metabolism, beta agonists appear to slow rates of protein turnover in adipose tissue.
ISSN:	0024-3205 1879-0631
DOI:	10.1016/0024-3205(91)90407-3