Serotonin-stimulated phospholipase A2 and collagenase activation in chondrocytes from human osteoarthritic articular cartilage

We have previously described several receptors on the chondrocyte membrane. In an attempt to further characterize the coupling mechanisms of serotoninergic receptors, here we examined the involvement of serotonin in the phospholipase A2 activity. Serotonin dose-dependently stimulated phospholipase A...

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Veröffentlicht in:	FEBS letters 1991-01, Vol.278 (1), p.38-40
Hauptverfasser:	Richard, M., Vignon, E., Peschard, M.J., Broquet, P., Carret, J.P., Louisot, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biological and medical sciences Cartilage, Articular - enzymology Cartilage, Articular - pathology Cell physiology Chondrocyte Collagenase Endopeptidases - metabolism Enzyme Activation Fundamental and applied biological sciences. Psychology Humans Metalloendopeptidases Microbial Collagenase - biosynthesis Microbial Collagenase - metabolism Middle Aged Molecular and cellular biology Osteoarthritis Osteoarthritis - enzymology Phospholipase A2 Phospholipases A - biosynthesis Phospholipases A - metabolism Phospholipases A2 Responses to growth factors, tumor promotors, other factors Serotonin Serotonin - physiology
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Zusammenfassung:	We have previously described several receptors on the chondrocyte membrane. In an attempt to further characterize the coupling mechanisms of serotoninergic receptors, here we examined the involvement of serotonin in the phospholipase A2 activity. Serotonin dose-dependently stimulated phospholipase A2. This activation enhanced collagenase type II activity and had no effect on proteoglycanase activity.
ISSN:	0014-5793 1873-3468
DOI:	10.1016/0014-5793(91)80078-H