Trisomy 5 in Ph+ chronic myeloid leukemia in association with megakaryocytosis

A patient with a megakaryocytosis associated with a Philadelphia chromosome-positive chronic myeloid leukemia (CML) was found to have a trisomy of chromosome five. To our knowledge, this is the first case of trisomy 5 associated with a Ph+ CML, particularly one with a megakaryocytosis. The trisomy 5...

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Veröffentlicht in:	Cancer genetics and cytogenetics 1991-02, Vol.51 (2), p.273-275
Hauptverfasser:	Ansell, Stephen M., Rapoport, Bernardo L., Coccia-Portugal, Maria A., Stevens, Kenneth, Bester, Catharina J., Falkson, Geoffrey
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromosomes, Human, Pair 5 Humans Karyotyping Leukemia, Myelogenous, Chronic, BCR-ABL Positive - diagnosis Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Male Megakaryocytes - pathology Middle Aged Trisomy
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Zusammenfassung:	A patient with a megakaryocytosis associated with a Philadelphia chromosome-positive chronic myeloid leukemia (CML) was found to have a trisomy of chromosome five. To our knowledge, this is the first case of trisomy 5 associated with a Ph+ CML, particularly one with a megakaryocytosis. The trisomy 5 may be associated with the resistance to cytostatic drugs found in this patient.
ISSN:	0165-4608 1873-4456
DOI:	10.1016/0165-4608(91)90141-G