Suppressive effects of dehydroepiandrosterone and 3β-methyl-androst-5-en-17-one on attack towards lactating female intruders by castrated male mice. II. Brain neurosteroids

Dehydroepiandrosterone (DHA) and 3β-methyl-androst-5en-17-one (CH3-DHA) suppress attacks by castrated male mice towards lactating female intruders (Haug et al. Physiol. Behav. 46:955, 1989). Their effects on the concentrations of DHA, pregnenolone (Δ5P), and their sulfate ester (S) have been investi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemical and biophysical research communications 1991-01, Vol.174 (2), p.892-897
Hauptverfasser:	Young, J., Corpéchot, C., Haug, M., Gobaille, S., Baulieu, E.E., Robel, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggression - drug effects Androstenes - pharmacology Animals Biological and medical sciences Brain - drug effects Brain - metabolism Dehydroepiandrosterone - metabolism Dehydroepiandrosterone - pharmacology Female Fundamental and applied biological sciences. Psychology Lactation Male Mice Orchiectomy Pregnenolone - metabolism Steroid hormones. Cholecalciferol derivatives Steroids - metabolism Testosterone - metabolism Vertebrates: endocrinology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Dehydroepiandrosterone (DHA) and 3β-methyl-androst-5en-17-one (CH3-DHA) suppress attacks by castrated male mice towards lactating female intruders (Haug et al. Physiol. Behav. 46:955, 1989). Their effects on the concentrations of DHA, pregnenolone (Δ5P), and their sulfate ester (S) have been investigated in the brain of control and treated mice. A more than 2 fold, significant, decrease of Δ5P-S was the only change common to both steroids. DHA and CH3-DHA effects might be related to the antagonistic action of Δ5P-S on GABAA receptors.
ISSN:	0006-291X 1090-2104
DOI:	10.1016/0006-291X(91)91501-3