Involvement of p34cdc2 in establishing the dependency of S phase on mitosis

Mutants of cdc2+ can disrupt the dependency of S phase on completion of the previous mitosis. By changing the state of p34cdc2 it is possible to reprogramme a cell from entering mitosis to undergoing S phase. This leads to the proposal that the cell cycle can be considered a p34cdc2 cycle, and has i...

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Veröffentlicht in:	Nature (London) 1991-01, Vol.349 (6308), p.388-393
Hauptverfasser:	BROEK, D, BARTLETT, R, CRAWFORD, K, NURSE, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cdc2 protein CDC2 Protein Kinase - physiology Cell Cycle Cell division Cell metabolism, cell oxidation Cell physiology Chromosomes Deoxyribonucleic acid Dependence DNA DNA Replication Evolution Fundamental and applied biological sciences. Psychology Fungal Proteins - metabolism Genes Kinases Life cycles Mitosis Molecular and cellular biology Molecular biology Mutation Nitrogen - metabolism Proteins S Phase Schizosaccharomyces - cytology Schizosaccharomyces - genetics Yeast
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Beschreibung
Zusammenfassung:	Mutants of cdc2+ can disrupt the dependency of S phase on completion of the previous mitosis. By changing the state of p34cdc2 it is possible to reprogramme a cell from entering mitosis to undergoing S phase. This leads to the proposal that the cell cycle can be considered a p34cdc2 cycle, and has implications for the evolution of life cycles.
ISSN:	0028-0836 1476-4687
DOI:	10.1038/349388a0