Absolute structure-cytotoxic activity relationships of steganacin congeners and analogues

Absolute structure-cytotoxic activity relationships of steganacin congeners and analogues

The cytotoxic activities of optically pure and racemic steganacin congeners and analogues against KB cells in culture and the inhibitor activity of cilia regeneration in Tetrahymena were studied with regard to absolute and relative configurations. The stereochemical requirements of dibenzocyclooctad...

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Veröffentlicht in:Journal of medicinal chemistry 1991, Vol.34 (1), p.54-57
Hauptverfasser: TOMIOKA, K, ISHIGURO, T, MIZUGUCHI, H, KOMESHIMA, N, KOGA, K, TSUKAGOSHI, S, TSURUO, T, TASHIRO, T, TANIDA, S, KISHI, T
Format: Artikel
Sprache:eng
Schlagworte:
4-Butyrolactone - analogs & derivatives
4-Butyrolactone - chemical synthesis
4-Butyrolactone - pharmacology
Antineoplastic agents
Antineoplastic Agents, Phytogenic - chemical synthesis
Biological and medical sciences
Cell Division - drug effects
General aspects
Humans
Indicators and Reagents
KB Cells
Lignans
Medical sciences
Models, Molecular
Molecular Conformation
Molecular Structure
Pharmacology. Drug treatments
Structure-Activity Relationship
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Zusammenfassung:The cytotoxic activities of optically pure and racemic steganacin congeners and analogues against KB cells in culture and the inhibitor activity of cilia regeneration in Tetrahymena were studied with regard to absolute and relative configurations. The stereochemical requirements of dibenzocyclooctadiene lignan lactones for activity were clarified.
ISSN:0022-2623
1520-4804
DOI:10.1021/jm00105a009