Activity and Distribution of Binding Sites in Brain of a Nonpeptide Substance P (NK$_1$) Receptor Antagonist

CP-96,345, a nonpeptide substance P antagonist, is selective for the tachykinin NK$_1$ receptor. The compound binds to a single population of sites in guinea pig brain and potently inhibits substance P-induced excitation of locus ceruleus neurons. CP-96,345 should be a useful tool for studying the a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Science (American Association for the Advancement of Science) 1991-01, Vol.251 (4992), p.437-439
Hauptverfasser:	McLean, Stafford, Ganong, Alan H., Seeger, Thomas F., Bryce, Dianne K., Pratt, Kara G., Reynolds, Linda S., Siok, Chester J., Lowe, John A., Heym, James
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Anatomy & physiology Animals Antagonists Autoradiography Binding Sites Binding sites (Biochemistry) Binding, Competitive Biological and medical sciences Biphenyl Compounds - metabolism Biphenyl Compounds - pharmacology Brain Brain - diagnostic imaging Brain - metabolism Cell receptors Cell structures and functions Corpus Striatum - diagnostic imaging Corpus Striatum - metabolism Fundamental and applied biological sciences. Psychology Guinea Pigs Hydrogen-Ion Concentration Locus coeruleus Male Molecular and cellular biology Nervous system Neurons Neuropeptide receptors Peptides Radionuclide Imaging Receptors Receptors, Neurokinin-1 Receptors, Neurotransmitter - antagonists & inhibitors Receptors, Neurotransmitter - metabolism Receptors, Tachykinin Spectrophotometry Substance P Substance P - metabolism Tachykinins Tachykinins - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	CP-96,345, a nonpeptide substance P antagonist, is selective for the tachykinin NK$_1$ receptor. The compound binds to a single population of sites in guinea pig brain and potently inhibits substance P-induced excitation of locus ceruleus neurons. CP-96,345 should be a useful tool for studying the action of substance P in the central nervous system.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.1703324