Red blood cell targeting to collagen-coated surfaces
The interaction of human red blood cells carrying antihuman collagen antibody with collagen-coated surfaces was studied. Avidin was used as bifunctional crosslinking agent for the attachment of antibody to the red blood cell surface. Antibody-carrying red blood cells efficiently and specifically bou...
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| Veröffentlicht in: | FEBS letters 1983-04, Vol.154 (2), p.257-261 |
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| container_title | FEBS letters |
| container_volume | 154 |
| creator | Samokhin, G.P. Smirnov, M.D. Muzykantov, V.R. Domogatsky, S.P. Smirnov, V.N. |
| description | The interaction of human red blood cells carrying antihuman collagen antibody with collagen-coated surfaces was studied. Avidin was used as bifunctional crosslinking agent for the attachment of antibody to the red blood cell surface. Antibody-carrying red blood cells efficiently and specifically bound to collagen-coated surface covering a significant part of the surface. The components of normal blood had an insignificant effect on red blood cell binding. A model of drug targeting to the injured sites(s) of blood vessel wall is proposed. |
| doi_str_mv | 10.1016/0014-5793(83)80160-4 |
| format | Article |
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Avidin was used as bifunctional crosslinking agent for the attachment of antibody to the red blood cell surface. Antibody-carrying red blood cells efficiently and specifically bound to collagen-coated surface covering a significant part of the surface. The components of normal blood had an insignificant effect on red blood cell binding. A model of drug targeting to the injured sites(s) of blood vessel wall is proposed.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/0014-5793(83)80160-4</identifier><identifier>PMID: 6832367</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Antibody attachment ; Antibody Specificity ; Avidin ; Biotin ; Chemical Phenomena ; Chemistry ; Collagen - immunology ; Collagen Avidin ; Drug targeting ; Erythrocytes ; Humans ; Red blood cell</subject><ispartof>FEBS letters, 1983-04, Vol.154 (2), p.257-261</ispartof><rights>1983</rights><rights>FEBS Letters 154 (1983) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4664-6c041a3fa1c8adb951cd385b2345fecd1fd15192a43a82db11e6bded7c7c538e3</citedby><cites>FETCH-LOGICAL-c4664-6c041a3fa1c8adb951cd385b2345fecd1fd15192a43a82db11e6bded7c7c538e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0014-5793(83)80160-4$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6832367$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Samokhin, G.P.</creatorcontrib><creatorcontrib>Smirnov, M.D.</creatorcontrib><creatorcontrib>Muzykantov, V.R.</creatorcontrib><creatorcontrib>Domogatsky, S.P.</creatorcontrib><creatorcontrib>Smirnov, V.N.</creatorcontrib><title>Red blood cell targeting to collagen-coated surfaces</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>The interaction of human red blood cells carrying antihuman collagen antibody with collagen-coated surfaces was studied. Avidin was used as bifunctional crosslinking agent for the attachment of antibody to the red blood cell surface. Antibody-carrying red blood cells efficiently and specifically bound to collagen-coated surface covering a significant part of the surface. The components of normal blood had an insignificant effect on red blood cell binding. A model of drug targeting to the injured sites(s) of blood vessel wall is proposed.</description><subject>Antibody attachment</subject><subject>Antibody Specificity</subject><subject>Avidin</subject><subject>Biotin</subject><subject>Chemical Phenomena</subject><subject>Chemistry</subject><subject>Collagen - immunology</subject><subject>Collagen Avidin</subject><subject>Drug targeting</subject><subject>Erythrocytes</subject><subject>Humans</subject><subject>Red blood cell</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkFFLwzAUhYMoc07_gUKfRB-qSZOm2YugY1NhIIg-hzS5HZGumUmr7N_b2LFHEQIh55x7cvkQOif4hmDCbzEmLM2LKb0S9Fr0Ck7ZARoTUdCUMi4O0XgfOUYnIXzg_i3IdIRGXNCM8mKM2CuYpKydM4mGuk5a5VfQ2maVtC7Rrq7VCppUO9X2udD5SmkIp-ioUnWAs909Qe-L-dvsKV2-PD7P7pepZpyzlGvMiKKVIlooU05zog0VeZlRllegDakMyck0U4wqkZmSEOClAVPoQudUAJ2gy6F3491nB6GVaxvimqoB1wUpMMMF46QPsiGovQvBQyU33q6V30qCZYQlIwkZSUjRnwhLsn7sYtfflWsw-6Ednd5fDP63rWH7r065mD9k0Yi6oL9q_OhuKIKe1pcFL4O20Ggw1oNupXH2701_AHxvi0A</recordid><startdate>19830418</startdate><enddate>19830418</enddate><creator>Samokhin, G.P.</creator><creator>Smirnov, M.D.</creator><creator>Muzykantov, V.R.</creator><creator>Domogatsky, S.P.</creator><creator>Smirnov, V.N.</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19830418</creationdate><title>Red blood cell targeting to collagen-coated surfaces</title><author>Samokhin, G.P. ; Smirnov, M.D. ; Muzykantov, V.R. ; Domogatsky, S.P. ; Smirnov, V.N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4664-6c041a3fa1c8adb951cd385b2345fecd1fd15192a43a82db11e6bded7c7c538e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Antibody attachment</topic><topic>Antibody Specificity</topic><topic>Avidin</topic><topic>Biotin</topic><topic>Chemical Phenomena</topic><topic>Chemistry</topic><topic>Collagen - immunology</topic><topic>Collagen Avidin</topic><topic>Drug targeting</topic><topic>Erythrocytes</topic><topic>Humans</topic><topic>Red blood cell</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Samokhin, G.P.</creatorcontrib><creatorcontrib>Smirnov, M.D.</creatorcontrib><creatorcontrib>Muzykantov, V.R.</creatorcontrib><creatorcontrib>Domogatsky, S.P.</creatorcontrib><creatorcontrib>Smirnov, V.N.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Samokhin, G.P.</au><au>Smirnov, M.D.</au><au>Muzykantov, V.R.</au><au>Domogatsky, S.P.</au><au>Smirnov, V.N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Red blood cell targeting to collagen-coated surfaces</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>1983-04-18</date><risdate>1983</risdate><volume>154</volume><issue>2</issue><spage>257</spage><epage>261</epage><pages>257-261</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>The interaction of human red blood cells carrying antihuman collagen antibody with collagen-coated surfaces was studied. Avidin was used as bifunctional crosslinking agent for the attachment of antibody to the red blood cell surface. Antibody-carrying red blood cells efficiently and specifically bound to collagen-coated surface covering a significant part of the surface. The components of normal blood had an insignificant effect on red blood cell binding. A model of drug targeting to the injured sites(s) of blood vessel wall is proposed.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>6832367</pmid><doi>10.1016/0014-5793(83)80160-4</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-5793 |
| ispartof | FEBS letters, 1983-04, Vol.154 (2), p.257-261 |
| issn | 0014-5793 1873-3468 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80407461 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Antibody attachment Antibody Specificity Avidin Biotin Chemical Phenomena Chemistry Collagen - immunology Collagen Avidin Drug targeting Erythrocytes Humans Red blood cell |
| title | Red blood cell targeting to collagen-coated surfaces |
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