Red blood cell targeting to collagen-coated surfaces

Red blood cell targeting to collagen-coated surfaces

The interaction of human red blood cells carrying antihuman collagen antibody with collagen-coated surfaces was studied. Avidin was used as bifunctional crosslinking agent for the attachment of antibody to the red blood cell surface. Antibody-carrying red blood cells efficiently and specifically bou...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:FEBS letters 1983-04, Vol.154 (2), p.257-261
Hauptverfasser: Samokhin, G.P., Smirnov, M.D., Muzykantov, V.R., Domogatsky, S.P., Smirnov, V.N.
Format: Artikel
Sprache:eng
Schlagworte:
Antibody attachment
Antibody Specificity
Avidin
Biotin
Chemical Phenomena
Chemistry
Collagen - immunology
Collagen Avidin
Drug targeting
Erythrocytes
Humans
Red blood cell
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The interaction of human red blood cells carrying antihuman collagen antibody with collagen-coated surfaces was studied. Avidin was used as bifunctional crosslinking agent for the attachment of antibody to the red blood cell surface. Antibody-carrying red blood cells efficiently and specifically bound to collagen-coated surface covering a significant part of the surface. The components of normal blood had an insignificant effect on red blood cell binding. A model of drug targeting to the injured sites(s) of blood vessel wall is proposed.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(83)80160-4