Immunotherapy of colon cancer metastases in rats with the immunostimulant OM-89

In a model of colon cancer in rats the bacterial extract OM-89 was found to have antitumor properties. We have shown that OM-89 induced the complete regression of numerous peritoneal tumor nodules measuring 1–5 mm in 46% of rats, and inhibited the growth of microscopic tumors in 42% of rats. OM-89 w...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Anti-cancer drugs 1990-12, Vol.1 (2), p.143-148
Hauptverfasser:	Lagadec, P, Onler, N, Bauer, J, Tourne, S, Jeannin, J F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - adverse effects Adjuvants, Immunologic - therapeutic use Administration, Oral Animals Antigens, Bacterial Ascitic Fluid - therapy Colonic Neoplasms - secondary Colonic Neoplasms - therapy Female Immunotherapy Injections, Intraperitoneal Lipopolysaccharides - administration & dosage Male Peritoneal Neoplasms - secondary Peritoneal Neoplasms - therapy Rats
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	In a model of colon cancer in rats the bacterial extract OM-89 was found to have antitumor properties. We have shown that OM-89 induced the complete regression of numerous peritoneal tumor nodules measuring 1–5 mm in 46% of rats, and inhibited the growth of microscopic tumors in 42% of rats. OM-89 was effective when injected ip at the dose of 50 mg/kg, twice a week for 2 weeks. It was ineffective at the same dose when given orally every day for 14 or 21 days. The traces of en-dotoxins (0.0005%) were probably not involved in the antitumor effect of OM-89. No side-effects were observed.
ISSN:	0959-4973 1473-5741
DOI:	10.1097/00001813-199012000-00005