Role of Surface-Active Phospholipids in Gastric Cytoprotection

Intragastric administration of a liposomal surfactant suspension markedly reduced acid-induced gastric ulcerogenesis and bleeding in rats. The concentration of surface-active molecules intrinsically present in the gastric mucosa was increased two to six times by administration of 16,16-dimethyl pros...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1983-03, Vol.219 (4590), p.1327-1329
Hauptverfasser:	Lichtenberger, Lenard M., Graziani, Lynne A., Dial, Elizabeth J., Butler, Bruce D., Hills, Brian A.
Format:	Artikel
Sprache:	eng
Schlagworte:	16,16-dimethyl prostaglandin E2 Animals Bleeding Gastric mucosa Gastric Mucosa - physiology Hemoglobins Indomethacin - pharmacology Lipids Liposomes mucosa Mucous membrane Phosphatidylcholines phospholipid composition Phospholipids Phospholipids - physiology Physiological aspects Prostaglandins Prostaglandins - physiology Rats Space life sciences Stomach Stomach diseases Stomach Ulcer - physiopathology Surface-Active Agents Surfactants
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Beschreibung
Zusammenfassung:	Intragastric administration of a liposomal surfactant suspension markedly reduced acid-induced gastric ulcerogenesis and bleeding in rats. The concentration of surface-active molecules intrinsically present in the gastric mucosa was increased two to six times by administration of 16,16-dimethyl prostaglandin E$_{2}$. Thus, local accumulation of surface-active phospholipids may be an integral component of the cytoprotective mechanism activated by prostaglandin treatment.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.6828859