On the influence of amezinium on various vascular regions of the dog

The action of amezinium is mediated by endogenous noradrenaline, and owing to the varying density of adrenergic neurons in the vascular system amezinium contracts predominantly vascular sections which are densely innervated. Hence, amezinium apparently displays an effect only in those regions where...

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Veröffentlicht in:	General pharmacology 1983, Vol.14 (1), p.163-165
Hauptverfasser:	Kretzschmar, R., Lehmann, H.D., Lenke, D., Raschack, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Pressure - drug effects Dogs Hemodynamics - drug effects In Vitro Techniques Muscle, Smooth, Vascular - drug effects Myocardial Contraction - drug effects Norepinephrine - pharmacology Pyridazines - pharmacology Regional Blood Flow - drug effects Renal Circulation - drug effects Sympathomimetics - pharmacology Time Factors
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Beschreibung
Zusammenfassung:	The action of amezinium is mediated by endogenous noradrenaline, and owing to the varying density of adrenergic neurons in the vascular system amezinium contracts predominantly vascular sections which are densely innervated. Hence, amezinium apparently displays an effect only in those regions where circulatory regulation is effected by local release of noradrenaline.
ISSN:	0306-3623 1879-0011
DOI:	10.1016/0306-3623(83)90092-7