Spontaneous tumors of the prostate gland in inbred strains of mice

Spontaneous tumors of the prostate gland in inbred strains of mice

Spontaneous tumors of the prostate gland in the house mouse (Mus musculus) have rarely been described. In a histologic survey of prostate glands from old (greater than 700 days of age) mice, we have observed 2 primary adenocarcinomas of the prostate gland, 1 in a 1,047-day-old C57BL/6J mouse (DEH 10...

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Veröffentlicht in:JNCI : Journal of the National Cancer Institute 1983-01, Vol.70 (1), p.199-208
Hauptverfasser: Waymouth, C, Coman, D R, Ward-Bailey, P F
Format: Artikel
Sprache:eng
Schlagworte:
Adenocarcinoma - pathology
Aging
Animals
Male
Mice
Mice, Inbred C57BL
Mice, Inbred Strains
Neoplasms, Experimental - pathology
Prostate - growth & development
Prostatic Neoplasms - pathology
Species Specificity
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Zusammenfassung:Spontaneous tumors of the prostate gland in the house mouse (Mus musculus) have rarely been described. In a histologic survey of prostate glands from old (greater than 700 days of age) mice, we have observed 2 primary adenocarcinomas of the prostate gland, 1 in a 1,047-day-old C57BL/6J mouse (DEH 1009) and 1 with metastases to the kidney and lungs in a 778-day-old C57BL/KsJ mouse (DEH 705C). We have also found a rhabdomyosarcoma of the prostate gland in a C57BL/6J mouse (DEH 1121C) 732 days old. The histologic characteristics of these tumors, and of the prostate glands of mice of similar ages without prostatic neoplastic involvement, including a 736-day-old CBA/CaJ mouse (DEH 849) with adenomatous hyperplasia, are described.
ISSN:0027-8874